TB-500 Spray
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What is TB-500 Spray?
Chemical Structure of TB-500 Spray
TB-500 is a linear peptide consisting of 43 amino acids with the sequence corresponding to human thymosin beta-4. Key structural characteristics include:
- Peptide length: 43 amino acids in linear configuration
- Molecular formula: C212H350N56O78S
- Molecular weight: Approximately 4.9 kDa
- Structural type: Actin-sequestering peptide with beta-sheet secondary structure
- Functional domains: N-terminal actin-binding domain (residues 1-16) and C-terminal region
- Binding motifs: Contains LKKTET sequence critical for G-actin interaction
- Post-translational modifications: N-terminal acetylation in endogenous form
- Formulation: Synthetic peptide dissolved in research-grade solvent system for spray delivery
The peptide contains a highly conserved actin-binding sequence that enables it to form 1:1 complexes with monomeric G-actin, thereby regulating actin filament assembly and cellular motility processes in experimental systems.
What Are the Effects of TB-500 Spray?
Laboratory and preclinical studies have documented the following research applications and observed effects:
Cellular Pathways Studied:
- Actin polymerization and depolymerization dynamics
- Focal adhesion formation and cell migration mechanisms
- Angiogenesis and endothelial cell tube formation
- Wound healing cascade and tissue remodeling processes
Mechanisms of Action:
- G-actin sequestration preventing spontaneous filament nucleation
- Promotion of actin filament severing and pointed-end capping
- Enhancement of cellular motility through cytoskeletal reorganization
- Modulation of integrin-mediated cell-matrix interactions
Research Applications:
- Cell migration and motility studies in scratch-wound assays
- Angiogenesis investigation using endothelial cell culture models
- Cytoskeletal dynamics research in live-cell imaging systems
- Comparative studies with other actin-binding proteins and peptides
Experimental Models:
- In vitro: Primary cell cultures, endothelial cell lines, fibroblast migration assays
- Ex vivo: Aortic ring angiogenesis assays, tissue explant cultures
- In vivo: Laboratory animal wound healing and vascular development models
- Biochemical assays: Actin polymerization assays, cell adhesion measurements, migration tracking
Research findings contribute to understanding actin cytoskeleton regulation, cell motility mechanisms, angiogenesis processes, and tissue repair biology in controlled laboratory environments.
TB-500 Spray
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2026-01-20
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Jcoop
2026-01-16
Amazing service top-notch products
Amazing service top-notch products, I always receive my peptides within a few days of placing my order.
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2026-01-16
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