TB-500 Spray
$99.99
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Availability: 19 in stock
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99%+ PURITY
MADE IN USA
What is TB-500 Spray?
TB-500 is a synthetic fragment of Thymosin Beta-4 (Tβ4), a naturally occurring peptide involved in actin regulation, cell migration, and tissue repair signaling pathways. This intranasal formulation offers researchers an alternative, non-invasive administration route for studying TB-500’s systemic distribution and bioavailability relative to traditional subcutaneous reconstitution methods. TB-500 remains a frequently referenced compound in models examining cytoskeletal dynamics and cellular migration.
Research Applications
TB-500 spray is commonly referenced in scientific literature exploring:
- Actin regulation and cytoskeletal dynamics research
- Cell migration and tissue repair signaling pathway studies
- Angiogenesis and vascular remodeling models
- Intranasal peptide delivery and mucosal bioavailability studies
- Comparative pharmacokinetics versus subcutaneous TB-500 administration
Product Specifications
| Attribute | Detail |
|---|---|
| Compound | TB-500 (Thymosin Beta-4 Fragment) |
| Delivery Format | Intranasal spray |
| Form | Pre-formulated liquid spray |
| Purity | Third-party HPLC verified |
| Storage | Refrigerate at 2–8°C; protect from light |
Quality Assurance
Each batch is verified via high-performance liquid chromatography (HPLC) to confirm purity, with a Certificate of Analysis (CoA) available for this lot. All peptides are handled and shipped under conditions designed to preserve compound stability and structural integrity.
This product is sold exclusively for research and laboratory purposes. It is not a drug, food, or cosmetic, and is not intended for human or animal consumption, diagnostic, or therapeutic use. By purchasing, the buyer confirms they are a qualified researcher or institution and agrees to handle this compound in accordance with all applicable laws and regulations.
Chemical Structure of TB-500 Spray
TB-500 is a linear peptide consisting of 43 amino acids with the sequence corresponding to human thymosin beta-4. Key structural characteristics include:
- Peptide length: 43 amino acids in linear configuration
- Molecular formula: C212H350N56O78S
- Molecular weight: Approximately 4.9 kDa
- Structural type: Actin-sequestering peptide with beta-sheet secondary structure
- Functional domains: N-terminal actin-binding domain (residues 1-16) and C-terminal region
- Binding motifs: Contains LKKTET sequence critical for G-actin interaction
- Post-translational modifications: N-terminal acetylation in endogenous form
- Formulation: Synthetic peptide dissolved in research-grade solvent system for spray delivery
The peptide contains a highly conserved actin-binding sequence that enables it to form 1:1 complexes with monomeric G-actin, thereby regulating actin filament assembly and cellular motility processes in experimental systems.
What Are the Effects of TB-500 Spray?
Laboratory and preclinical studies have documented the following research applications and observed effects:
Cellular Pathways Studied:
- Actin polymerization and depolymerization dynamics
- Focal adhesion formation and cell migration mechanisms
- Angiogenesis and endothelial cell tube formation
- Wound healing cascade and tissue remodeling processes
Mechanisms of Action:
- G-actin sequestration preventing spontaneous filament nucleation
- Promotion of actin filament severing and pointed-end capping
- Enhancement of cellular motility through cytoskeletal reorganization
- Modulation of integrin-mediated cell-matrix interactions
Research Applications:
- Cell migration and motility studies in scratch-wound assays
- Angiogenesis investigation using endothelial cell culture models
- Cytoskeletal dynamics research in live-cell imaging systems
- Comparative studies with other actin-binding proteins and peptides
Experimental Models:
- In vitro: Primary cell cultures, endothelial cell lines, fibroblast migration assays
- Ex vivo: Aortic ring angiogenesis assays, tissue explant cultures
- In vivo: Laboratory animal wound healing and vascular development models
- Biochemical assays: Actin polymerization assays, cell adhesion measurements, migration tracking
Research findings contribute to understanding actin cytoskeleton regulation, cell motility mechanisms, angiogenesis processes, and tissue repair biology in controlled laboratory environments.
TB-500 Spray
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Frequently asked questions
TB-500 Spray is supplied as a pre-filled nasal spray bottle, arriving in a ready-prepared liquid format rather than as a dry vial.
The difference is the delivery format and presentation, not the compound itself: the spray arrives pre-filled, while the TB-500 vial is supplied as a dry powder.
Every lot of TB-500 Spray is lab-tested to the ≥99% purity benchmark used across the catalog, and a Certificate of Analysis accompanies each shipment.
It means TB-500 Spray is intended solely for in-vitro study. It is not a therapeutic product and may not be used in or on humans or animals.
Yes. Each unit of TB-500 Spray carries a lot number that links back to its production batch and the corresponding Certificate of Analysis.
