Thymalin
$119.00
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99%+ PURITY
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What is Thymalin?
Chemical Structure of Thymalin
Thymalin’s active nonapeptide, thymulin, possesses the sequence Pyr–Ala–Lys–Ser–Gln–Gly–Gly–Ser–Asn–OH, with a molecular weight of 858.9 Da (PubChem CID 3085284). The preparation also contains short dipeptides (EW, KE) and a tripeptide (EDP), which contribute to its biological activity by interacting with DNA and histone proteins to epigenetically modulate gene expression linked to immune and regenerative functions.
What Are the Effects of Thymalin?
- Lymphocyte Differentiation & Immune Regulation: Thymalin enhances differentiation of hematopoietic stem cells (HSCs) into mature CD28⁺ T‑lymphocytes, while reducing markers such as CD117 and CD44 associated with immature or apoptotic cells.
- Immunomodulation & Anti‑Inflammatory Action: It suppresses excessive pro-inflammatory cytokine production (e.g., IL‑1β, IL‑6, TNF‑α) and promotes regulatory cytokines, acting via NF‑κB and MAPK pathways in LPS stimulation models.
- Hematopoiesis & Regeneration: Thymalin normalizes hematopoietic function by supporting T and B cell populations, NK cell activity, and blood coagulation balance during recovery after chemotherapy or infection.
- Geroprotection & Aging Resistance: Studies in aged animals show regulation of gerontogenes and heat shock proteins, structural restoration of immunity, and reduced infection incidence—supporting its role in geroprotective mechanisms.
- Epigenetic Gene Regulation: The EW and KE peptide components bind histones and double-stranded DNA to modulate transcription of immune-related genes, including those involved in inflammation, regeneration, fibrinolysis, and apoptotic pathways.
Citations
- PubChem Compound Summary for Thymulin (CID 3085284): sequence Pyr–Ala–Lys–Ser–Gln–Gly–Gly–Ser–Asn; MW 858.9 Da.
- peptides.guide entry “Thymalin”: immunomodulatory short peptide complex, T/NK cell regulation.
- Khavinson VKh, Linkova NS, Chalisova NI, Ivko OM, “The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity,” Biology Bulletin Reviews.
- Khavinson VKh, Kuznik BI, Shapovalov KG, et al. “Peptide Drug Thymalin Regulates Immune Status in Severe COVID‑19 Older Patients,” Advances in Gerontology.
- peptides.guide: sequence and formula details.
- Shao Y, et al. “Immunomodulatory effect of Thymalin active peptides EW and KE in LPS‑induced inflammation” Int J Mol Sci.
- Morozov VG & Khavinson VK. “Natural and synthetic thymic peptides as therapeutics for immune dysfunction,” Int. J. Immunopharmacol.
Thymalin
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Frequently asked questions
Thymalin is supplied as a lyophilized (freeze-dried) research peptide in a sealed vial.
Freeze-drying removes moisture so the contents stay shelf-stable as a dry powder during storage and transit until they are prepared in a research setting.
Yes. Each batch of Thymalin is independently lab-tested to ≥99% purity, and the matching COA is included with your order.
It means Thymalin is intended solely for in-vitro study. It is not a therapeutic product and may not be used in or on humans or animals.
Thymalin counts toward your order total, and US orders over $300 ship free; all orders are sent discreetly within 2–5 day US shipping.
